The two-match Test series will get underway on August 12 in Jamaica.
Fast bowler Chemar Holder and middle-order batsman Shamarh Brooks have received recall to the squad.
Holder made his Test debut in New Zealand last year but has not featured since then. On the other hand, Brooks last played in New Zealand and has earned a recall following a polished century in the Best v Best four-day match last week.
Moreover, two experienced players, left-hander Darren Bravo and fast bowler Shannon Gabriel will not feature in the home series versus Pakistan.
Roger Harper, Lead Selector of the Senior Men's Team said: "Chemar Holder returns, having recovered from his injury. He will bolster the fast bowling department. Shamarh Brooks batted his way into the provisional squad by scoring an accomplished century. He will certainly add some depth to the squad's batting."
"Shannon Gabriel has been given time to rehab fully and build his conditioning, so he was not part of the preparations for the Test series against Pakistan, which included the Best v Best game. Darren Bravo has been part of the 'bubble' from the preparation camp leading into the Betway Test series against South Africa and has been given a break," he added.
The first Test is due to be played from August 12-16 while the second game is set to be held from August 20-24. Kingston, Jamaica will host both the Test matches, which will be part of the second World Test Championship (WTC) cycle.
West Indies Test Squad:
Kraigg Brathwaite (c), Jermaine Blackwood, Nkrumah Bonner, Shamarh Brooks, Rahkeem Cornwall, Roston Chase, Joshua Da Silva, Jahmar Hamilton, Chemar Holder, Jason Holder, Shai Hope, Alzarri Joseph, Kyle Mayers, Kieran Powell, Kemar Roach, Jayden Seales, Jomel Warrican.