Pakistan suffered yet another whitewash down under.
While Lyon returned with figures of 5/69, pacer Josh Hazlewood wasn't far behind taking 3/63.
Shan Masood (68) and Asad Shafiq (57) scored half-centuries but the rest of the Pakistani batting line-up struggled badly, a disappointing theme followed throughout the last two weeks.
Earlier in the game, Australia piled on a mountain-like 589/3 (declared) with David Warner scoring an epic 335 not out and Marnus Labuschagne contributing a solid 162. These were their second 100+ scores for the series.
The only time Pakistan bowled, left-arm seamer Shaheen Afridi (3/88) got all the breakthroughs while his partners were smashed around the park.
In response, the first Test centurion Babar Azam continued his excellent form through a solid 97 and capable lower-order batsman Yasir Shah had the moment of his tour with a rare maiden century batting No.8.
But those two were the only ones who provided some fight as Pakistan succumbed to 302 all out.
Mitchell Starc bowled a fantastic spell and bagged figures of 6/63 in the first innings.
This was Pakistan's 14th straight Test defeat in Australia.
Brief Scores:
Australia 589/3 declared (David Warner 335*; Shaheen Afridi 3/88) defeated Pakistan 302/10 (Yasir Shah 113; Mitchell Starc 6/63) & 239/10 (Shan Masood 68; Nathan Lyon 5/69) by an innings and 48 runs