Mott has been the head coach of Australia women's team since 2015.
Mott, 48, has signed a four-year agreement and is expected to be in place for England's three-match ODI series against The Netherlands in Amsterdam next month.
The ECB's selection panel of Chief Executive Officer Tom Harrison, Managing Director of England's Men's Cricket Rob Key, Strategic Adviser Andrew Strauss, and Performance Director Mo Bobat unanimously agreed that he was the standout candidate for the role during the competitive interview process.
Mott has been in charge of the Australia women’s team since 2015 and under his coaching, they have won consecutive ICC T20 World Cups, this year's ICC Women's 50-Over World Cup and are undefeated in four Ashes series. Australia women also remained undefeated in 26 ODI matches consecutively, a record in either the men's or women's game.
Commenting on the appointment of Mott, Managing Director of England's Men's Cricket Rob Key, said: "It is a real privilege to be able to announce Mathew Mott as the Head Coach of our men's white-ball team. He has had an incredible coaching journey with so many varied experiences that have brought him to this point where he was outstanding in the interview process and the perfect fit for our white-ball teams.
We are lucky to be able to appoint a Head Coach that has not only been involved in international cricket for the last few years but he has also worked in franchise cricket around the world. More importantly, what he has done with the Australian Women's team is what will be asked of him to achieve for our men's white-ball sides.”
"I'm confident that in Eoin Morgan and Matthew Mott, we have a formidable partnership that can push for more trophies in the coming years and that Matthew will be able to oversee any transition that team will go through in the future,” he added.
England Men's White-Ball Head Coach, Matthew Mott, added: "I am delighted to accept the opportunity to take this white-ball role with England. Whilst I am Australian, I have deep connections, and several of my closest friends are in the UK, having spent considerable time in Scotland, Wales and England, both as a player and coach. When this role became available, I was attracted by the chance to work with such an established and successful team under the astute leadership of Eoin Morgan and now Rob Key, whom I have always admired as an excellent cricket mind.
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It was always going to take something special to leave the role that I have loved for the past seven years with the Australian Women's team. However, I genuinely believe that the time is right to play a role in helping the England Men's ODI and T20 group continue to evolve as one of the best teams in the world.”
He added: "Since the excitement of accepting this role, I, like many people around the world, have been trying to come to terms with the tragic loss of my great mate Andrew Symonds. The support of his beautiful family and close friends in the coming days will be vitally important, so I respectfully request some time to process his passing and the immense loss before making any further comment on the role at this stage."
(ECB inputs)