Rassie van der Dussen also made huge gains after his performance in India ODI series.
De Kock broke into the top five spots for the first time since the ICC Men's Cricket World Cup 2019 after aggregating 229 runs that included a match-winning 124 in the final match in Cape Town and was named the Player of the Series as well.
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Van der Dussen, who scored 218 runs, has advanced 10 places to reach a career-best 10th position. Opener Shikhar Dhawan, the leading scorer for India against South Africa with 169 runs, has moved up one place to 15th in the list led by Pakistan captain Babar Azam with Virat Kohli and Rohit Sharma in second and joint-third positions, respectively. Rishabh Pant is up to five places to 82nd.
South African pacer Lungi Ngidi is back in the top 20 after five wickets in the series and spinner Keshav Maharaj is at a career-best 33rd position.
(ANI inputs)