India reduced Australia to 2/2 after being asked to bowl first.
Siraj, bowling his first over of the match, produced an outswinger to hit Khawaja’s pads. A loud lbw appeal followed but umpire Nitin Menon didn't raise the finger, which led to Siraj persuading skipper Rohit Sharma to go upstairs.
Rohit consulted with wicketkeeper KS Bharat and opted for DRS. The ball tracker showed three reds as Khawaja walked back to the pavilion after scoring 1 off 3 balls.
The wicket via DRS saw the home team roaring in jubilation and coach Dravid also celebrated with passion while sitting in the dressing room.
In the very next over, Mohammad Shami struck for India, castling David Warner with a peach of a delivery for just 1 off 5 balls.
After Warner’s dismissal, the visitors found themselves reeling at 2/2 after 2.1 overs. Earlier, Australia skipper Pat Cummins won the toss and elected to bat first.
The tourists handed an international debut cap to off-spinner Todd Murphy on a Nagpur pitch expected to assist the spinners.