The India skipper will return home post the first Test in Adelaide.
Vaughan said while Kohli's decision to return home to attend to the birth of his first child is absolutely "right", the flip side, however, is that the home team will "quite easily" be able to regain the Border-Gavaskar Trophy.
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"No @imVkohli for 3 Tests in Australia .. The right decision going to be at the birth of his first child .. but it means Australia will win the series quite easily IMO," tweeted Vaughan on Tuesday (November 10).
There have been mix reactions to Kohli's leave for the Test matches in Melbourne, Sydney and Brisbane. While some are criticising it over social media, many have praised him for rightfully prioritising his family and wife, Anushka Sharma, at their most cherished moment.
The Indian captain and inarguably the world's best batsman will be travelling to Australia on November 12 from Dubai for the limited-overs leg, which starts off the tour on November 27, and his team's historic first away D/N Test from December 17.
In Kohli's absence, vice-captain Ajinkya Rahane is likely to step-up, although there have been suggestions made to appoint Rohit Sharma, Kohli's white-ball deputy and five-time IPL winning captain, as the leader for the final three Tests.