Samuels has earlier vented out his anger on Ben Stokes and Shane Warne.
The ex-England skipper recently slammed Samuels for his derogatory Instagram stories on Ben Stokes, which brimmed with racism.
See Also: Ben Stokes reacts to Marlon Samuels's derogatory comments on his family
In an Instagram story, Samuels took a dig at a news article which reported Vaughan’s stance on this controversy.
The Caribbean cricketer also boasted about his wealth and his fragrance brand named Sextillion, which according to him is making a lot of money, something which Vaughan can never imagine.
It all started after Stokes recently spoke about the challenges of quarantine. The English all-rounder quipped that he wouldn't wish the process on his "worst enemy" Marlon Samuels.
However, Stokes’ comment didn’t go down well with Samuels as the West Indian called the English cricketer a “b****”, followed by further derogatory remarks on his wife and legendary Australia spinner Shane Warne.
Reacting on this matter, Warne had tweeted: "I have just been sent what Samuels has posted re @benstokes38 & I. It is a very sad situation as he obviously needs serious help-but has no friends at all and not even his ex-teammates like him. Just because you were an ordinary cricketer-no need to be an ordinary person. Get help son."
Stokes and Samuels’ rivalry goes back to 2015 when the duo indulged in a heated exchange during England's tour of West Indies. It all started in the second Test at St George's when Samuels amusingly saluted the English all-rounder after his dismissal.
During the all-important 2016 ICC World T20 final at Eden Gardens, Samuels was at the other end when Carlos Brathwaite smashed Stokes for 4 consecutive sixes to seal the deal for West Indies. On that occasion, Samuels rejoiced the triumph in front of Stokes, who described the Jamaican as someone who "lacks respect" in his autobiography.