Mignon du Preez became the first South African player, male or female, to play 100 T20Is.
Natalie Sciver made 50 and Amy Jones made 23 as England managed to make 123/8 in 20 overs. Ayabonga Khaka picked 3/25, while Marizanne Kapp and Van Niekerk picked two wickets apiece.
However, Mignon du Preez, who was playing her 100th T20I, kept her cool, making 18* in 11 balls to take her team home with 2 balls to spare. South Africa made 127/4 and won the match by six wickets. For England, Sophie Ecclestone picked 2/19, while Shrubsole and Glenn picked one each.
Dane van Niekerk got the Player of the Match for her 46 and two wickets.
BRIEF SCORES:
ENG-W 123/8 (N SCIVER 50; A KHAKA 3/25) lost to SA-W 127/4 (D VAN NIEKERK 46; S ECCLESTONE 2/19) by 6 wickets