West Indies leads the 5-match T20I series 2-1.
Hetmyer has struggled for form over the last few weeks with scores of 1 and 2 in the first two T20Is against England. He was not part of the XI for the third T20I, which West Indies lost thanks to Harry Brook’s heroics.
Earlier, he had scores of 32, 0, and 12 in the three ODIs. He is replaced by Johnson Charles who played the most recent of his 44 T20Is against India in August.
Alzarri Joseph has been rested ahead of the West Indies' tour of Australia next month which includes two Tests, three ODIs, and three T20Is. The pacer is likely to be part of all three formats on the tour that begins with the opening Test in Adelaide on January 17.
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Joseph put in a key display in the second T20I with 3 for 39 - claiming the wickets of Phil Salt, Will Jacks, and Sam Curran.
Fellow fast bowler Oshane Thomas comes into the squad for the final two matches of the series in Trinidad.
West Indies squad for last two T20Is vs England:
Rovman Powell (capt), Shai Hope, Johnson Charles, Roston Chase, Matthew Forde, Jason Holder, Akeal Hosein, Brandon King, Kyle Mayers, Gudakesh Motie, Nicholas Pooran, Andre Russell, Sherfane Rutherford, Romario Shepherd, Oshane Thomas
(ESPNCricinfo inputs)