South Africa will play three ODIs and as many T20Is against West Indies at home from March 16 to March 28.
Aiden Markram will take over as the T20I captain from Temba Bavuma, who relinquished the position last month.
Recently, Markram tasted success as skipper as he led Sunrisers Eastern Cape to the inaugural SA 20 title.
"I would like to congratulate Aiden on his appointment as captain of the Proteas T20I team," Enoch Nkwe, CSA’s Director of Cricket, congratulated Markram on his appointment.
"Leadership is extremely familiar to him having successfully led on so many levels. He is a player that inspires confidence and he has all the qualities to succeed in the role. We have no doubt will help take South Africa to the next level.
"At the same time, we would like to thank Temba for filling the position so aptly over the past two years. He has done a commendable job during this period and now has a new role to fulfil within the national set-up.”
For the ODI series, Anrich Nortje and Kagiso Rabada have been rested while Gerald Coetzee, Ryan Rickelton, Tony de Zorzi and Tristan Stubbs have received a maiden call-up to the squad.
Bjorn Fortuin and Sisanda Magala have also been named in the ODI squad, which misses several notable names from the first two games but they return for the third match.
"This is a squad that is high on confidence after beating one of the best white-ball teams in the world, England, in their most recent series," head coach Rob Walter said.
"We have introduced a few new faces to the 50-over squad. I am personally excited to see how the likes of Tony de Zorzi gets on in the ODI team, the same with Gerald Coetzee, following debuts for both of them during the ongoing Test series.
"Both are players that have the potential to play a huge role in the future of the national team along with Tristan Stubbs, who has already made such a significant mark in the T20I arena.
"I am also excited to have Aiden take the reigns as T20I captain as he is very familiar to the setup and works well with those around him. He is a player that leads from the front and we have no doubt he will take this team to the next level in the years ahead."
South Africa will play three ODIs and as many T20Is against West Indies at home from March 16 to March 28.
South Africa squad for first two ODIs: Temba Bavuma (captain), Gerald Coetzee, Quinton de Kock, Tony de Zorzi, Bjorn Fortuin, Reeza Hendricks, Sisanda Magala, Keshav Maharaj, Wiaan Mulder, Lungi Ngidi, Ryan Rickelton, Andile Phehlukwayo, Tristan Stubbs, Lizaad Williams, Rassie van der Dussen.
South Africa squad for third and final ODI: Temba Bavuma (captain), Gerald Coetzee, Quinton de Kock, Tony de Zorzi, Bjorn Fortuin, Reeza Hendricks, Marco Jansen, Heinrich Klaasen, Sisanda Magala, Keshav Maharaj, Aiden Markram, David Miller, Wiaan Mulder, Lungi Ngidi, Ryan Rickelton, Wayne Parnell, Andile Phehlukwayo, Tristan Stubbs, Lizaad Williams, Rassie van der Dussen.
South Africa squad for three T20Is: Aiden Markram (captain), Quinton de Kock, Bjorn Fortuin, Reeza Hendricks, Marco Jansen, Heinrich Klaasen, Sisanda Magala, David Miller, Lungi Ngidi, Anrich Nortje, Wayne Parnell, Kagiso Rabada, Rilee Rossouw, Tabraiz Shamsi, Tristan Stubbs.