Plunkett represented England in 13 Tests, 89 ODIs and 22 T20s picking 201 wickets.
Plunkett will leave Surrey after three years with the club and will join Philadelphians, a team that contests in the eastern division of the minor cricket league.
The pacer played an important role in England’s World Cup triumph in 2019. He picked 3/42, including the wicket of New Zealand captain Kane Williamson in the final.
"I would like to thank everyone at Surrey for the support and backing I have received over the last three years. It is an incredible Club, and it was an honor to have represented them. Moving onto the next phase of my career, I'm thrilled to have the opportunity to join Major League Cricket and focus my attention on helping to grow the sport in the United States.
I've enjoyed a fantastic career with England, and after retiring from international cricket, I am delighted to be able to help build the sport in America in both playing and coaching capacities,” Liam Plunkett said to the Surrey CCC website.
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"In addition, I am looking forward to supporting the team closest to our home in the US by being able to play for The Philadelphians in Minor League Cricket," he said.
Surrey CCC Director of Cricket, Alec Stewart said: "On behalf of everyone at the Club, we wish Liam the very best with his new challenge in America. Whenever he is in London, he will always be welcomed back to visit the Kia Oval."
Liam Plunkett represented England in 13 Tests, 89 ODIs, and 22 T20s and picked up 201 international wickets.