The young leg-spinner had picked up a leg injury before the ODI series versus Zimbabwe.
The 22-year-old missed the entire ODI series after injuring his leg during a warm-up match in Lahore on October 23.
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"The leg-spinner is recovering well from his injury, but he is advised for more rest," stated Pakistan Cricket Board (PCB) in a media release. "The decision to include Shadab in the remaining T20I matches will take place in due course. Shadab suffered from stiffness in his left upper-leg during the first intra-squad warm-up match in Lahore on October 23."
On Wednesday (November 4), PCB released Abid Ali, Imam-ul-Haq and Haris Sohail from the squad upon completion of the ICC Super League fixtures with the Zimbabweans. The three cricketers will now be able to take part in the ongoing first-class season.
The second and third T20Is will be played on November 8 and 10, respectively.
Pakistan T20I squad: Babar Azam, Haider Ali, Abdullah Shafique, Fakhar Zaman, Mohammad Hafeez, Khushdil Shah, Mohammad Rizwan, Iftikhar Ahmed, Faheem Ashraf, Imad Wasim, Rohail Nazir, Shadab Khan, Shaheen Afridi, Mohammad Hasnain, Haris Rauf, Musa Khan, Wahab Riaz, Usman Qadar and Zafar Gohar
(Inputs from ANI)