Marizanne Kapp and Laura Wolvaardt have bagged four nominations each in the women's category.
Both the cricketers have been nominated for South Africa Men's Cricketer of the Year, ODI Cricketer of the Year and T20 Cricketer of the Year gone by.
De Kock has also been nominated to possibly receive the Test Cricketer of the Year award with Kagiso Rabada and Anrich Nortje and South Africa Men's Players' Players award.
Among women cricketers, all-rounder Marizanne Kapp and batsman Laura Wolvaardt have been nominated for as many as four categories.
"It is my great pleasure and privilege to congratulate all the nominees as we celebrate the achievements of both our Proteas men's and women's squads," CSA acting CEO Jacques Faul said in a media release.
"And, while we are doing that, let us not forget to thank all those great and selfless people who work diligently behind the scenes to create opportunities for our leading cricketers to excel."
"Our country continues to produce world-class players. Quinton de Kock, Kagiso Rabada, Faf du Plessis and Imran Tahir all rank among the top men's players in the world across the various formats and I think we have all been excited to see new faces such as Anrich Nortje and Janneman Malan who have emerged in the past year."
The awards will be handed over to Proteas' top performers in a virtual ceremony on July 4 due to travelling restrictions in place amid the ongoing COVID-19 pandemic.